New Mass Spec Solution Simplifies Analysis of Macromolecular Complexes

新的解决方案能够同时检测以前无法测量的分析

An innovative mass spectrometry solution from Thermo Fisher Scientific Inc provides proteomics and biopharmaceutical laboratories, working in drug discovery and R&D applications, the ability to clearly decipher complex mixtures of large macromolecules.

TheThermo Scientific Direct Mass Technology modeaugmentsThermo Scientific Q Exactive UHMR Hybrid Quadrupole-Orbitrap mass spectrometers具有电荷检测能力，允许在一个光谱中直接测定数百到数千个单个离子的质量。As a result, laboratories can measure mass for complex heterogeneous mixtures of multiple charged components, unlocking new and rich insights into proteoforms, biotherapeutics and next-generation drug modalities.

“Direct Mass Technology mode combines charge detection with our trusted high-resolution accurate mass Orbitrap measurements to achieve results unattainable by current ensemble measurement techniques,” said Iain Mylchreest, Vice President, Research and Development, Analytical Instruments, Thermo Fisher Scientific. “By dissolving the complexity barriers inherent to other approaches, we’re enabling a wealth of investigations that were once firmly out of reach - from resolving heavily modified proteoforms to revealing small changes in large antibody-drug conjugate complexes, to name but a few.”

Neil Kelleher, Director, Northwestern Proteomics & the Chemistry of Life Processes Institute, Northwestern University, said: “The differences seen when moving from traditional mass spectrometry to this game-changing direct mass technology are profound. We’ve gone from having no data or uninterpretable data to having rich spectra laying bare proteoform complexity. With such solutions, we no longer need to be overwhelmed by the complexity of the human proteome. This technology makes clear that, ultimately, we can build tools that match the complexity and scale of our biology.”