Assessment of Minimal Amounts of Sample Useful for Pharmaceutical Actives and Early Stage Formulations

The 2005 AAPS Annual Meeting & Exposition saw the US launch of new accessories forFreeman TechnologyFT4粉体流变仪。这些是全自动的，小体积的剪切单元，可以用来测量体积到3ml或更少，取决于粉末的特性。这个全新的模块使用户能够扩展FT4剪切测试的应用范围，包括那些只有少量样品可用的测试。这包括许多药物活性物质和材料，如早期制剂，必须在有限的供应上进行广泛的试验。

The FT4 is a universal powder rheometer that is used to conduct an array of powder flowability tests. These provide a means to characterize the flow properties of powder materials and relate them to performance in process. Where shear testing is required to complement flowability data, both the new small volume shear cell and the existing standard shear cell accessory offer significant advantages over conventional methods.

Shear testing using the FT4 is fully automated, minimizing operator involvement for greater repeatability and reproducibility of results. And it is fast, with tests completed in around 40 minutes. Measurements can be made at low levels of material consolidation, thanks to the system's high sensitivity, and over a wide range of stresses up to 100 kPa, allowing simulation of many different packing conditions. Conditioning of material before testing ensures homogeneity and a high degree of repeatability.