Combination offers Possibilities in Workflow Improvement

Microscope and imaging systems manufacturer Leica Microsystems has formed a partnership with French start-up Alvéole with aims to make micropatterning with proteins more accessible to researchers for controlling the spatial organisation and biochemical microenvironment of cells.

Alvéole的生物工程平台与徕卡显微镜的结合提供了精确控制细胞形状和标准细胞培养基质生长的潜力，也为电子断层摄影工作流程中使用的特殊基质，特别是EM栅格。这大大提高了低温断层扫描工作流程中的可访问性和吞吐量，因为所需的目标细胞现在生长在显微镜的理想位置，而不是在较难访问的区域。

“We are very excited by how quickly many researchers have improved their cryo-electron tomography workflow and throughput thanks to our PRIMO micropatterning system. The partnership with Leica is a unique opportunity to accelerate these improvements and to provide the best possible tools for reproducible, efficient and simple cryo-ET cell sample preparation,” said Alvéole Marketing Manager, Marie-Charlotte Manus.

“几十年来，徕卡微系统一直在开发和提供优秀的工具和工作流程解决方案，使低温电子显微镜的研究。在与Thermo Fisher科学公司的合作中，我们精简了低温电子断层扫描工作流程，从骤降冻结到数据分析。然而，EM网格上细胞的可及性放置是一个主要障碍。现在与Alvéole合作，我们正在解决这个问题的PRIMO微模式系统。该系统确保了细胞在EM网格正方形的中间生长，大大增加了TEM和SEM调查的可访问性，”Julia博士补充道König，莱卡微系统的产品经理。

The first joint communications was in June with the launch of a webinar series presented by a common client (Professor Elizabeth Wright - Morgridge Institute for Research University of Wisconsin-Madison, US).

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